Pfizer, Moderna’s Covid vaccines no longer linked to baby defects after first trimester shot, learn about revelations

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Top Line

There is no evidence of primary birth defects in young babies born to mothers who were vaccinated against COVID-19 during the first trimester of pregnancy, according to unpublished research published in JAMA Pediatrics on Monday. Emphasizes on security. The unfortunate condition comes amid growing evidence of the dangers the infection can pose to mothers and young children.

Main information

A promotional visual of Pfizer and Moderna’s mRNA Covid vaccines during the first trimester of pregnancy was “not associated with an increased risk” of primary birth defects, including problems with the ears, neural tube, kidneys, respiratory system and musculoskeletal system. Taking into account a team of researchers from across the US

The findings come from a study of health care data covering more than 42,000 pregnancies involving live births between the beginning of March 2021 and the end of January 2022 across 8 health care systems in California, Oregon, Washington, Colorado, Minnesota was registered in the Vaccine Protection Datalink database. , and Wisconsin.

About 7,600 of the pregnant women who received a dose of mRNA Covid vaccine during the first trimester — one of the most likely categories of pregnancy for negative effects and birth defects — did not, the researchers said, adding that 19,000 did not before pregnancy. Or receiving the vaccine during pregnancy and 13,500 getting a dose in their second or third trimester, but not in their first trimester.

The researchers said this dose was the second vaccine for about 1,350 pregnant women vaccinated in their first trimester, with about 46% going on to receive their second dose during the second or third trimester and 20% receiving . Third booster dose.
The researchers said their findings point to a greater likelihood of primary structural birth defects after first-trimester vaccination, calling on some additional research from Scotland and Israel to comprehensively assess the association between maternal vaccination and birth defects in infants. Are.
The findings, which span only Pfizer and Moderna’s COVID-19 vaccines, “should provide reassurance to pregnant people and their obstetric care physicians,” the researchers said.

main background

Researchers and officials are naturally very cautious about introducing newly licensed healthcare products to the pregnant society because of the risks to the parent and child. This is very true early in pregnancy, when the risk of exposure to potential hazards is higher and for newer generations, such as mRNA vaccines, which have been less extensively studied in the community than more established products and from drug manufacturers. Is. Exclude pregnant society from trials over safety issues. This warning was on full display throughout the COVID-19 pandemic in the early stages of the vaccine rollout, when photos were untouched and not much was known about the virus and its dangers to pregnant women and babies. There was little to no disagreement about vaccination in the pregnant society and all experts and health companies around the world, including the International Fitness Group, were divided on how to travel, sometimes discouraging and sometimes encouraging the pregnant society. . Getting vaccinated. Mavens and Supremacy Condition Executives now widely encourage pregnant society to get vaccinated immediately and there is a wide range of evidence that mothers are protected from Covid infection, including breathing problems, premature delivery, stillbirth and neurological and developmental And exposes the child to the dangers of a serious condition. Problem. The analysis also suggests that maternal vaccination may provide protection to the child within the first six months of the next delivery.

tangent line

The Centers for Disease Control and Prevention recommends vaccination at any stage of pregnancy and says that studies involving thousands of people around the world show that vaccination before and during pregnancy is safe and effective and “for Is recommended. Both the pregnant person and the child.” The CDC said mRNA vaccines reduce the risk of unpleasant complications and various conditions from COVID-19 during pregnancy, while also helping to create protective antibodies that can provide protection to the baby. The company emphasizes that “the benefits of receiving the COVID-19 vaccine outweigh any potential risks of vaccination during pregnancy.”

what we don’t know

Information about unwanted side effects, especially unusual side effects, may take up to a month to emerge and is limited to capture fairly small pattern sizes like the pregnant society. The researchers said their findings only considered out-of-wedlock births as well as pregnancies ending in live births, which would naturally exclude any defects that could lead to stillbirth or a similar outcome, as it The information was not recorded in the available databases. , Some alternative problems may take time to emerge, the researchers said, and although they were only able to assess defects up to four months from birth, they said this hourly framework has proven to have a certain predictive value in the future. .

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