Recent study confirms that chemicals are continuously absorbed through human skin.

A study on 17 commonly used synthetic ‘forever chemicals’ has revealed that these toxic elements can be easily absorbed through human skin.

Latest analysis, printed status global The first hour proves that a wide range of PFAS (perfluoroalkyl substances) – chemical substances that do not degrade in nature – can cross the surface barrier and reach the body’s bloodstream.

PFAS are largely obsolete in industries and consumer products ranging from school uniforms to personal aid products due to their aqua and stain-resistant properties. Although some agents have been blocked by government legislation, others are still largely outdated and their toxic effects have not yet been fully investigated.

PFAS are already known to enter the body through a variety of routes, for example by inhalation or ingestion through food or drinking water, and they are associated with adverse health effects such as reduced response to vaccination, chronic Known to cause liver damage. Like and the delivery weight reduced.

It is generally believed that PFAS are not capable of breaking surface barriers, however recent research has shown an association between exposure to personal care products and PFAS concentrations in human blood and breast milk. The untested study is essentially the most comprehensive assessment to date of the absorption of PFAS into human skin and confirms that most of them can enter the body through this course.

The study’s lead author, Dr. Odni Ragnarsdottir, received her Ph.D. Presented research for. At Birmingham College. He explained, “The ability of these chemicals to be absorbed through the skin has been ignored in the past because the molecules are ionized. The electrical rate that gives them the power to repel water and stains was thought to be The excess renders them unable to cross the surface membrane.

“Our research shows that this theory is not always true and that, in fact, absorption through the skin may be a significant source of exposure to these harmful chemicals.”

The researchers examined 17 other PFAS. The compounds chosen were among the oldest compounds known, and were commonly studied for their toxic effects and alternative ways in which humans could be exposed to them. Most importantly, they are compliant with regulated chemical substances through the EU’s Ingestive H2O Directive.

In their experiments, the group used older 3-D human skin-like models – multilayered lab-grown tissue that mimics what normal human skin houses, meaning the study could be conducted without the use of any animals. They applied samples of each chemical to measure what proportion was absorbed, unabsorbed, or retained in complete fashion.

Of the 17 PFAS tested, the group found that 15 elements actually showed widespread dermal absorption – at least 5% of the promoted dose. At the exposure dose tested, absorption into the bloodstream of the most regulated PFAS (perfluoro octanoic acid; PFOA) was 13.5%, with an additional 38% of the applied dose retained for potential long-term uptake in the skin. Stream.

The amount absorbed seemed as if it would correlate with the extent of carbon chains in the entire molecule. While elements with longer carbon chains showed lower levels of absorption, shorter chain compounds that were provided to replace longer carbon chain PFAS, such as PFOA, were more easily absorbed. For example, the absorption of perfluoropentanoic acid was 4 times that of PFOA at 59%.

Meet co-author, Dr. Mohammed Abdullah, who mentions, “Our study provides the first information about the importance of the dermal route as a route of exposure to a wide range of chemicals from ever-existing PFAS. Given the large numbers of exposures, it is important that future studies aim to assess the risk of a broader range of these toxic chemicals rather than focusing on one chemical at a time.”

Co-author Tutor Stuart Harradt, of the Birmingham College of Geography, Earth and Environmental Sciences, said: “This study is helping us to better understand how impactful exposure to these chemicals can be through surfaces and what impact Chemical structures can be most easily absorbed.

“This is important because we are seeing a shift in industry towards chemicals with shorter chain lengths as these are considered less toxic – although the trade-off may be that we absorb more of them, so we are less aware of the risks involved. Need to know more about.”